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The connection method of sanitary fittings directly affects the sealing performance, disassembly and assembly convenience, and cleaning effect of the system. The common connection forms mainly include clamp type, welding type, and threaded type. Clamp type connections (also known as quick install connections) are widely used in situations where frequent cleaning or component replacement is required due to their characteristics of no welding, easy disassembly and inspection. The connection is achieved by clamping the sealing gasket with two flange end faces and fastening it with stainless steel clamps for quick docking. Its advantages lie in easy installation, reliable sealing, and low technical requirements for operators, making it suitable for small and medium-sized pipeline systems.

Welded connections are divided into two types: automatic rail welding and manual argon arc welding, mainly used in permanent installation scenarios. Welded joints have excellent strength and sealing properties, capable of withstanding high pressure and temperature fluctuations, while eliminating potential leakage points and hygiene blind spots, making them particularly suitable for high-purity pharmaceutical systems. But the welding process needs to be operated by professional personnel and subjected to weld seam inspection to ensure the absence of defects such as cracks and pores. Threaded connections are often used for small equipment or instrument interfaces, commonly in NPT or BSPP standards. Although they are flexible to install, their application in high cleanliness environments is limited due to the possibility of dirt and grime accumulation in the thread gap, which increases the difficulty of cleaning. Therefore, in practical selection, a comprehensive judgment should be made based on system operating conditions, maintenance frequency, and industry standards, and priority should be given to selecting connection schemes that are conducive to clean validation and long-term stable operation.